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- Title
Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression.
- Authors
Radbill, Brian D; Gupta, Ritu; Ramirez, Maria Celeste M; DiFeo, Analisa; Martignetti, John A; Alvarez, Carlos E; Friedman, Scott L; Narla, Goutham; Vrabie, Raluca; Bowles, Robert; Saiman, Yedidya; Bansal, Meena B
- Abstract
Matrix metalloproteinase-2 (MMP-2), a type IV collagenase secreted by activated hepatic stellate cells (HSCs), is upregulated in chronic liver disease and is considered a profibrotic mediator due to its proliferative effect on cultured HSCs and ability to degrade normal liver matrix. Although associative studies and cell culture findings suggest that MMP-2 promotes hepatic fibrogenesis, no in vivo model has definitively established a pathologic role for MMP-2 in the development and progression of liver fibrosis. We therefore examined the impact of MMP-2 deficiency on liver fibrosis development during chronic CCl(4) liver injury and explored the effect of MMP-2 deficiency and overexpression on collagen I expression.
- Publication
Digestive diseases and sciences, 2011, Vol 56, Issue 2, p406
- ISSN
1573-2568
- Publication type
Journal Article
- DOI
10.1007/s10620-010-1296-0