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- Title
Naturally occurring glycoalkaloids in potatoes aggravate intestinal inflammation in two mouse models of inflammatory bowel disease.
- Authors
Iablokov, Vadim; Sydora, Beate C; Foshaug, Rae; Meddings, Jon; Driedger, Darcy; Churchill, Tom; Fedorak, Richard N
- Abstract
Inflammatory bowel disease (IBD) may be initiated following disruption of the intestinal epithelial barrier. This disruption, in turn, permits luminal antigens unfettered access to the mucosal immune system and leads to an uncontrolled inflammatory response. Glycoalkaloids, which are found in potatoes, disrupt cholesterol-containing membranes such as those of the intestinal epithelium. Glycoalkaloid ingestion through potatoes may play a role in the initiation and/or perpetuation of IBD.
- Publication
Digestive diseases and sciences, 2010, Vol 55, Issue 11, p3078
- ISSN
1573-2568
- Publication type
Journal Article
- DOI
10.1007/s10620-010-1158-9