We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Staphylococcal enterocolitis: forgotten but not gone?
- Authors
Zheng Lin; Kotler, Donald P.; Schlievert, Patrick M.; Sordillo, Emilia Mia; Lin, Zheng
- Abstract
<bold>Purpose: </bold>Staphylococcus aureus may cause antibiotic-associated diarrhea and enterocolitis, with or without preceding antibiotic use, in immunocompromised adults or infants, or individuals with predisposing conditions, but there is little appreciation of this condition clinically. CLINICAL DISEASE: The main clinical feature that helps to differentiate staphylococcal enterocolitis (SEC) from Clostridium difficile-associated diarrhea is large-volume, cholera-like diarrhea in the former case. A predominance of gram-positive cocci in clusters on gram stain of stool or biopsy specimens and the isolation of S. aureus as the dominant or sole flora support the diagnosis.<bold>Pathogenesis: </bold>The pathogenesis of SEC requires the interaction of staphylococcal enterotoxins, which function as superantigens, with interstitial epithelial lymphocytes and intestinal epithelial cells (IECs).<bold>Management: </bold>Most SEC represents recent S. aureus acquisition, so that improved infection prevention practices can reduce disease recurrence. Management should include aggressive fluid management and repletion and oral vancomycin.
- Publication
Digestive Diseases & Sciences, 2010, Vol 55, Issue 5, p1200
- ISSN
0163-2116
- Publication type
Academic Journal
- DOI
10.1007/s10620-009-0886-1