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- Title
Spatial regulation and organization of DNA replication within the nucleus.
- Authors
Natsume, Toyoaki; Tanaka, Tomoyuki U
- Abstract
Duplication of chromosomal DNA is a temporally and spatially regulated process. The timing of DNA replication initiation at various origins is highly coordinated; some origins fire early and others late during S phase. Moreover, inside the nuclei, the bulk of DNA replication is physically organized in replication factories, consisting of DNA polymerases and other replication proteins. In this review article, we discuss how DNA replication is organized and regulated spatially within the nucleus and how this spatial organization is linked to temporal regulation. We focus on DNA replication in budding yeast and fission yeast and, where applicable, compare yeast DNA replication with that in bacteria and metazoans.
- Publication
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2010, Vol 18, Issue 1, p7
- ISSN
1573-6849
- Publication type
Journal Article
- DOI
10.1007/s10577-009-9088-0