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- Title
Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE).
- Authors
Amigou, Alicia; Rudant, Jérémie; Orsi, Laurent; Goujon-Bellec, Stéphanie; Leverger, Guy; Baruchel, André; Bertrand, Yves; Nelken, Brigitte; Plat, Geneviève; Michel, Gérard; Haouy, Stéphanie; Chastagner, Pascal; Ducassou, Stéphane; Rialland, Xavier; Hémon, Denis; Clavel, Jacqueline
- Abstract
Fetal folate deficiency may increase the risk of subsequent childhood acute leukemia (AL), since folates are required for DNA methylation, synthesis, and repair, but the literature remains scarce. This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism.
- Publication
Cancer causes & control : CCC, 2012, Vol 23, Issue 8, p1265
- ISSN
1573-7225
- Publication type
Journal Article
- DOI
10.1007/s10552-012-0004-0