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- Title
Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer.
- Authors
Chan, June M; Weinberg, Vivian; Magbanua, Mark J; Sosa, Eduardo; Simko, Jeffry; Shinohara, Katsuto; Federman, Scot; Mattie, Mike; Hughes-Fulford, Millie; Haqq, Christopher; Carroll, Peter R
- Abstract
Nutritional factors are associated with reduced risk of prostate cancer progression, yet mechanisms remain unclear. We examined the effects of lycopene and fish oil supplements versus placebo on the normal prostate microenvironment, among men pursuing active surveillance for low-burden prostate cancer. We hypothesized that lycopene or fish oil supplements would down-regulate insulin-like growth factor-1 (IGF-1) and cyclooxygenase 2 (COX-2) gene expression, respectively, reflecting putative proliferation (IGF-1) and inflammatory (COX-2) pathways relevant to carcinogenesis.
- Publication
Cancer causes & control : CCC, 2011, Vol 22, Issue 1, p141
- ISSN
1573-7225
- Publication type
Journal Article
- DOI
10.1007/s10552-010-9684-5