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- Title
Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer.
- Authors
Tsilidis, Konstantinos K; Helzlsouer, Kathy J; Smith, Michael W; Grinberg, Victoriya; Hoffman-Bolton, Judith; Clipp, Sandra L; Visvanathan, Kala; Platz, Elizabeth A
- Abstract
The association of 17 candidate single nucleotide polymorphisms (SNPs) in IL10 and other immune response genes (CRP, TLR4, IL6, IL1B, IL8, TNF, RNASEL) and genes related to obesity (PPARG, TCF7L2, ADIPOQ, LEP) with colorectal cancer was investigated. Haplotype tagging SNPs were chosen for IL10, CRP, and TLR4. Incident colorectal cancer cases (n = 208) and matched controls (n = 381) were identified between baseline in 1989 and 2003 among participants in the CLUE II cohort. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression.
- Publication
Cancer causes & control : CCC, 2009, Vol 20, Issue 9, p1739
- ISSN
1573-7225
- Publication type
Journal Article
- DOI
10.1007/s10552-009-9427-7