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- Title
O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States).
- Authors
Tranah, Gregory J; Bugni, James; Giovannucci, Edward; Ma, Jing; Fuchs, Charles; Hines, Lisa; Samson, Leona; Hunter, David J
- Abstract
O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic adducts from the O6-position of guanine in DNA. Unrepaired O6-methylguanines result in G:C to A:T transitions in mutated K-ras and p53 in colorectal tumors. Two non-synonymous MGMT coding region variants, Leu84Phe and Ile143Val, lie in close proximity to the reactive 145Cys residue and to a conserved estrogen receptor interacting helix.
- Publication
Cancer causes & control : CCC, 2006, Vol 17, Issue 5, p721
- ISSN
0957-5243
- Publication type
Journal Article
- DOI
10.1007/s10552-006-0005-y