We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States).
- Authors
Jones, J Shawn; Gu, Xiangjun; Lynch, Patrick M; Rodriguez-Bigas, Miguel; Amos, Christopher I; Frazier, Marsha L
- Abstract
We examined a G-to-A single nucleotide polymorphism of the ATM gene, to determine if it influences hereditary non-polyposis colorectal cancer (HNPCC) age of onset. HNPCC is caused by mutations in mismatch repair genes, especially hMLH1 and hMSH2. ATM germline mutations have been associated with breast and digestive cancers. In a smaller European study, the G-to-A polymorphism was associated with an increased risk of developing an HNPCC-related cancer within HNPCC families.
- Publication
Cancer causes & control : CCC, 2005, Vol 16, Issue 6, p749
- ISSN
0957-5243
- Publication type
Journal Article
- DOI
10.1007/s10552-005-1540-7