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- Title
Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA era.
- Authors
Platz, Elizabeth A; Pollak, Michael N; Leitzmann, Michael F; Stampfer, Meir J; Willett, Walter C; Giovannucci, Edward
- Abstract
The insulin-like growth factor (IGF) axis is thought to contribute to the growth and progression of prostate cancer. Some prospective studies support a direct association between IGF-1 and prostate cancer, in particular advanced disease, whereas both inverse and direct associations with prostate cancer have been reported for insulin-like growth factor binding protein-3 (IGFBP-3), the major IGF-1 binding protein in circulation. We prospectively investigated the associations of plasma IGF-1 and IGFBP-3 concentrations with prostate cancer detected in the PSA era.
- Publication
Cancer causes & control : CCC, 2005, Vol 16, Issue 3, p255
- ISSN
0957-5243
- Publication type
Journal Article
- DOI
10.1007/s10552-004-3484-8