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- Title
RAD51 135G>C polymorphism contributes to breast cancer susceptibility: a meta-analysis involving 26,444 subjects.
- Authors
Wang, Zhanwei; Dong, Hairong; Fu, Yuanyuan; Ding, Haixia
- Abstract
RAD51 plays a key role in homologous recombination repair of double-stranded DNA breaks which may cause chromosomal breaks and genomic instability. We performed a meta-analysis of 9 epidemiological studies involving 13,241 cases and 13,203 controls that examined the association between RAD51 135G>C polymorphism and breast cancer. No significant association of RAD51 135G>C polymorphism with breast cancer was found in overall and European populations. However, after the studies which did not fulfill Hardy-Weinberg equilibrium were excluded, we observed an overall significant increased breast cancer risk (for the recessive model CC vs. GG/CG: OR = 1.35, 95% CI = 1.05-1.74, P (heterogeneity) = 0.06). In summary, our meta-analysis suggested the RAD51 135G > C polymorphism may contribute to breast cancer susceptibility.
- Publication
Breast cancer research and treatment, 2010, Vol 124, Issue 3, p765
- ISSN
1573-7217
- Publication type
Journal Article
- DOI
10.1007/s10549-010-0885-0