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- Title
Gene expression of topoisomerase II alpha (TOP2A) by microarray analysis is highly prognostic in estrogen receptor (ER) positive breast cancer.
- Authors
Rody, A; Karn, T; Ruckhäberle, E; Müller, V; Gehrmann, M; Solbach, C; Ahr, A; Gätje, R; Holtrich, U; Kaufmann, M
- Abstract
Overexpression of Topoisomerase II alpha (TOP2A) has been implicated with gene amplification of the 17q21 amplicon and consecutively with ErbB2 overexpression and amplification. However, gene amplification does not necessarily correlate with RNA and protein expression. There is growing evidence that TOP2A protein expression is a strong prognostic and TOP2A gene amplification might be a predictive marker (particularly for the use of anthracyclines).
- Publication
Breast cancer research and treatment, 2009, Vol 113, Issue 3, p457
- ISSN
1573-7217
- Publication type
Journal Article
- DOI
10.1007/s10549-008-9964-x