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- Title
Estrogen receptor co-activator (AIB1) protein expression by automated quantitative analysis (AQUA) in a breast cancer tissue microarray and association with patient outcome.
- Authors
Harigopal, Malini; Heymann, Jonas; Ghosh, Sriparna; Anagnostou, Valsamo; Camp, Robert L; Rimm, David L
- Abstract
Amplified in breast cancer (AIB1 or SRC-3) is an estrogen receptor coregulatory protein that together with other co-activators like transcription intermediary factor 2 (TIF2) and nuclear receptor co-repressor (NCoR), is implicated in estrogen signaling pathway and estrogen regulated tumor progression. We investigated the prognostic significance of AIB1, TIF2 & NCoR protein expression breast tissue microarray (TMA), and studied the relationship of coregulatory proteins to prognostic biomarkers like estrogen (ER), progesterone (PR) & HER2/neu and between coregulatory proteins.
- Publication
Breast cancer research and treatment, 2009, Vol 115, Issue 1, p77
- ISSN
1573-7217
- Publication type
Journal Article
- DOI
10.1007/s10549-008-0063-9