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- Title
Predicting response to primary chemotherapy: gene expression profiling of paraffin-embedded core biopsy tissue.
- Authors
Lida Mina; Sharon Soule; Sunil Badve; Fredrick Baehner; Joffre Baker; Maureen Cronin; Drew Watson; Mei-Lan Liu; George Sledge; Steve Shak; Kathy Miller
- Abstract
Abstract Purpose  Primary chemotherapy provides an ideal opportunity to correlate gene expression with response to treatment. We used paraffin-embedded core biopsies from a completed phase II trial to identify genes that correlate with response to primary chemotherapy. Patients and Methods  Patients with newly diagnosed stage II or III breast cancer were treated with sequential doxorubicin 75 mg/M2 q2 wks  3 and docetaxel 40 mg/M2 weekly  6; treatment order was randomly assigned. Pretreatment core biopsy samples were interrogated for genes that might correlate with pathologic complete response (pCR). In addition to the individual genes, the correlation of the Oncotype DX Recurrence Score with pCR was examined. Results  Of 70 patients enrolled in the parent trial, core biopsies samples with sufficient RNA for gene analyses were available from 45 patients; 9 (20%) had inflammatory breast cancer (IBC). Six (14%) patients achieved a pCR. Twenty-two of the 274 candidate genes assessed correlated with pCR (p p Conclusion  Gene expression analysis on core biopsy samples is feasible and identifies candidate genes that correlate with pCR to primary chemotherapy. Gene expression in IBC differs significantly from noninflammatory breast cancer.
- Publication
Breast Cancer Research & Treatment, 2007, Vol 103, Issue 2, p197
- ISSN
0167-6806
- Publication type
Academic Journal
- DOI
10.1007/s10549-006-9366-x