We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mitochondrial DNA transcription regulation and nucleoid organization.
- Authors
Rebelo, Adriana P; Dillon, Lloye M; Moraes, Carlos T
- Abstract
Mitochondrial biogenesis is a complex process depending on both nuclear and mitochondrial DNA (mtDNA) transcription regulation to tightly coordinate mitochondrial levels and the cell's energy demand. The energy requirements for a cell to support its metabolic function can change in response to varying physiological conditions, such as, proliferation and differentiation. Therefore, mitochondrial transcription regulation is constantly being modulated in order to establish efficient mitochondrial oxidative metabolism and proper cellular function. The aim of this article is to review the function of major protein factors that are directly involved in the process of mtDNA transcription regulation, as well as, the importance of mitochondrial nucleoid structure and its influence on mtDNA segregation and transcription regulation. Here, we discuss the current knowledge on the molecular mode of action of transcription factors comprising the mitochondrial transcriptional machinery, as well as the action of nuclear receptors on regulatory regions of the mtDNA.
- Publication
Journal of inherited metabolic disease, 2011, Vol 34, Issue 4, p941
- ISSN
1573-2665
- Publication type
Journal Article
- DOI
10.1007/s10545-011-9330-8