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- Title
Micro-well texture printed into PEG hydrogels using the FILM nanomanufacturing process affects the behavior of preadipocytes.
- Authors
David Fozdar; Xuemei Wu; Charles Patrick; Shaochen Chen
- Abstract
Abstract To date, biomaterial scaffolds for adipose tissue engineering have focused on macro- and upper micro-scale fabrication, biocompatibility, and biodegradation, but have failed to recapitulate the sub-micron dimensions of native extracellular matrix (ECM) and, therefore, have not optimized material–cell interactions. Here, we report the findings from a study investigating the effects of a quasi-mimetic sub-micron (Flash Imprint Lithography Using a Mask Aligner (FILM). FILM is a simple process that can be utilized to fabricate micro- and nanostructures in UV-curable materials (D.Y. Fozdar, W. Zhang, M. Palard, C.W. Patrick Jr., S.C. Chen, Flash Imprint Lithography Using A Mask Aligner (FILM): A Method for Printing Nanostructures in Photosensitive Hydrogels for Tissue Engineering. Nanotechnology 19, 2008). We demonstrate the utilization of the FILM process for a tissue engineering application for the first time. The micro-well topographical theme is characterized by contact angle and surface energy analysis and the results were compared with those for smooth glass and unpatterned PEGDMA surfaces. Based on our observations, we believe that the micro-well texture may ultimately be beneficial on implantable tissue scaffolds.
- Publication
Biomedical Microdevices, 2008, Vol 10, Issue 6, p839
- ISSN
1387-2176
- Publication type
Academic Journal
- DOI
10.1007/s10544-008-9198-z