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- Title
Antitumor activity of Mn(III) complexes in combination with phototherapy and antioxidant therapy.
- Authors
Pereira, Tatiana Araujo; da Silva, Gisele Espinha Teixeira; Hernández, Raúl Bonne; Forti, Fabio Luis; Espósito, Breno Pannia
- Abstract
Manganese (Mn) is an essential trace element and trivalent Mn complexes have been used as oxidation catalysts and enzyme mimetics. We studied the cytotoxicity of Mn(III) derivatives of citrate, pyrophosphate and salicylene diamine (respectively, MnCit, MnPPi and EUK8) toward HeLa cells stressed by ultraviolet irradiation and the effect of the co-administration of ascorbate and para-amino salicylate (PAS) on cell viability. Metal complexes enhanced the lethality of irradiated cells, and this effect was even more pronounced when ascorbate was co-administered with Mn(III) species. The active role of Mn(III) compounds in the antitumor activity was demonstrated by the treatment of the cells with the chelator PAS, which restored the viability of both non-irradiated and UV-irradiated cells. The association of the Mn(III) metallodrugs with radiation and an antioxidant proved to be a very effective approach to chemotherapy.
- Publication
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2013, Vol 26, Issue 3, p439
- ISSN
1572-8773
- Publication type
Journal Article
- DOI
10.1007/s10534-013-9626-2