We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A retrovirus-based system to stably silence hepatitis B virus genes by RNA interference.
- Authors
Fang Jia; Yi-Zheng Zhang; Chang-Mei Liu
- Abstract
RNA interference (RNAi) might be an efficient antiviral therapy for some obstinate illness. Herein, a retrovirus-based RNAi system was developed to drive expression and delivery of Hepatitis B virus (HBV)-specific short hairpin RNA (shRNA) in HepG2 cells. The levels of HBsAg and HBeAg and that of HBV mRNA were dramatically decreased by this RNAi system in HepG2 cells transfected with Topo-HBV plasmid. Retrovirus-based RNAi thus may be useful for therapy in HBV and other viral infections and provide new clues for prophylactic vaccine development.
- Publication
Biotechnology Letters, 2006, Vol 28, Issue 20, p1679
- ISSN
0141-5492
- Publication type
Academic Journal
- DOI
10.1007/s10529-006-9138-z