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- Title
Relationship Between mRNA Stability and Length: An Old Question with a New Twist.
- Authors
Liang Feng; Deng-Ke Niu
- Abstract
The half-life of individual mRNA plays a central role in controlling the level of gene expression. However, the determinants of mRNA stability have not yet been well defined. Most previous studies suggest that mRNA length does not affect its stability. Here, we show significant negative correlations between mRNA length and stability in human andEscherichia coli, but not inSaccharomyces cerevisiaeorBacillus subtilis. This finding suggests the possibility that endonucleolytic attacks by RNA endonuclease and/or mechanical damage may strongly influence mRNA stability in both prokaryotes and eukaryotes.
- Publication
Biochemical Genetics, 2007, Vol 45, Issue 1/2, p131
- ISSN
0006-2928
- Publication type
Academic Journal
- DOI
10.1007/s10528-006-9059-5