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- Title
Rat Blood Leukocytes after Intravenous Injection of Chitosan-Modified Magnetic Nanospheres.
- Authors
Milto, I V; Ivanova, V V; Shevtsova, N M; Sukhodolo, I V
- Abstract
Nanosized magnetite particles (magnetic nanospheres) are a prospective basis for creation of new diagnostic and therapeutic agents. The structure of blood leukocytes and the leukocytic formula are studied in adult rats over a period of 120 days after a single intravenous injection of chitosan-modified nanosized magnetite particles. No effects of chitosan-modified magnetic nanospheres on the structure of rat blood leukocytes are detected. Injection of suspension of chitosan-modified magnetite nanospheres is associated with an increase in the levels of monocytes, segmented and stab neutrophils, and a decrease in lymphocyte counts in the blood of rats. The shifts in the leukogram parameters are transitory, the picture returned to normal by day 40 postinjection.
- Publication
Bulletin of experimental biology and medicine, 2020, Vol 168, Issue 6, p785
- ISSN
1573-8221
- Publication type
Journal Article
- DOI
10.1007/s10517-020-04802-z