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- Title
N-acetyl cysteine enhances imatinib-induced apoptosis of Bcr-Abl+ cells by endothelial nitric oxide synthase-mediated production of nitric oxide.
- Authors
Rakshit, Srabanti; Bagchi, Jayashree; Mandal, Labanya; Paul, Kausik; Ganguly, Dipyaman; Bhattacharjee, Sandip; Ghosh, Monidipa; Biswas, Nabendu; Chaudhuri, Utpal; Bandyopadhyay, Santu
- Abstract
Imatinib, a small-molecule inhibitor of the Bcr-Abl kinase, is a successful drug for treating chronic myeloid leukemia (CML). Bcr-Abl kinase stimulates the production of H(2)O(2), which in turn activates Abl kinase. We therefore evaluated whether N-acetyl cysteine (NAC), a ROS scavenger improves imatinib efficacy.
- Publication
Apoptosis : an international journal on programmed cell death, 2009, Vol 14, Issue 3, p298
- ISSN
1573-675X
- Publication type
Journal Article
- DOI
10.1007/s10495-008-0305-7