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- Title
Microarray analysis of p-anisaldehyde-induced transcriptome of Saccharomyces cerevisiae.
- Authors
Lu Yu; Na Guo; Yi Yang; Xiuping Wu; Rizeng Meng; Junwen Fan; Fa Ge; Xuelin Wang; Jingbo Liu; Xuming Deng
- Abstract
p-Anisaldehyde (4-methoxybenzaldehyde), an extract from Pimpinella anisum L. seeds, is a potential novel preservative. To reveal the possible action mechanism of p-anisaldehyde against microorganisms, yeast-based commercial oligonucleotide microarrays were used to analyze the genome-wide transcriptional changes in response to p-anisaldehyde. Quantitative real-time RT-PCR was performed for selected genes to verify the microarray results. We interpreted our microarray data with the clustering tool, T-profiler. Analysis of microarray data revealed that p-anisaldehyde induced the expression of genes related to sulphur assimilation, aromatic aldehydes metabolism, and secondary metabolism, which demonstrated that the addition of p-anisaldehyde may influence the normal metabolism of aromatic aldehydes. This genome-wide transcriptomics approach revealed first insights into the response of Saccharomyces cerevisiae ( S. cerevisiae) to p-anisaldehyde challenge.
- Publication
Journal of Industrial Microbiology & Biotechnology, 2010, Vol 37, Issue 3, p313
- ISSN
1367-5435
- Publication type
Academic Journal
- DOI
10.1007/s10295-009-0676-y