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- Title
Temporary elimination of orthostatic hypotension by norepinephrine infusion.
- Authors
Goldstein, David S; Sewell, LaToya; Holmes, Courtney; Pechnik, Sandra; Diedrich, André; Robertson, David
- Abstract
A cardinal manifestation of chronic autonomic failure is neurogenic orthostatic hypotension (OH), which often is associated with supine hypertension, posing a therapeutic dilemma. We report here success in a first step toward development of a "prosthetic baroreceptor system" to maintain blood pressure during orthostasis without worsening supine hypertension. In all of four patients with neurogenic OH, titrated i.v. NE infusion kept directly recorded intra-arterial pressure at or above baseline during progressive head-up tilt. We conclude that titrated i.v. NE infusion temporarily eliminates OH.
- Publication
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2012, Vol 22, Issue 6, p303
- ISSN
1619-1560
- Publication type
Journal Article
- DOI
10.1007/s10286-012-0176-4