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- Title
The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids.
- Authors
Liu, Man-Chang; Maruyama, Shoichi; Mizuno, Masashi; Morita, Yoshiki; Hanaki, Shigeru; Yuzawa, Yukio; Matsuo, Seiichi
- Abstract
Although Aristolochia manshuriensis (AM), which was incriminated in the Japanese variety of Chinese herbs nephropathy, has been recently shown to be nephrotoxic in rats, less is known about whether this toxicity is attributable to its aristolochic acids (AA). We compared the renal effect of AM with that of Akebia quinata (AQ), which has similar components to AM but is free of AA; we also compared this effect of AM with that of pure AA, and studied its possible mechanism.
- Publication
Clinical and experimental nephrology, 2003, Vol 7, Issue 3, p186
- ISSN
1342-1751
- Publication type
Journal Article
- DOI
10.1007/s10157-003-0229-z