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- Title
The efficacy of high-dose penicillin for community-acquired pneumonia diagnosed by pneumococcal urine antigen test.
- Authors
Hideaki Oka; Atsuhisa Ueda; Yuji Watanuki; Jun Tsukiji; Hideyo Kuroda; Syunsuke Akashi; Yoshihiro Hirai; Toshiharu Fuyuki; Takeshi Kaneko; Yoshiaki Ishigatsubo
- Abstract
Abstract We analyzed the efficacy of both the Streptococcus pneumoniae urine antigen test as a quick diagnostic tool and the administration of high-dose penicillin in response to a positive S. pneumoniae urine antigen test. We conducted a retrospective analysis of 48 cases of pneumococcal pneumonia, in which the patients were treated with high-dose penicillin. All the cases were diagnosed by a positive urine antigen test. Treatment with high-dose penicillin was effective in 43 of the 48 patients. This treatment was also effective in 12 of 16 culture-confirmed cases with low susceptibility to penicillin. Eleven patients who were positive for the S. pneumoniae urine antigen test but culturenegative showed clinical improvement with high-dose penicillin. Pneumonia caused by S. pneumoniae appeared to be treated safely and effectively with high-dose penicillin based on positive results of the urine antigen test, as penicillin resistance was unlikely to be a problem.
- Publication
Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.), 2009, Vol 15, Issue 2, p108
- ISSN
1341-321X
- Publication type
Academic Journal
- DOI
10.1007/s10156-009-0672-1