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- Title
Gray matter atrophy in progressive supranuclear palsy: meta-analysis of voxel-based morphometry studies.
- Authors
Shi, Hai Cun; Zhong, Jian Guo; Pan, Ping Lei; Xiao, Pei Rong; Shen, Yuan; Wu, Li Juan; Li, Hua Liang; Song, Yuan Ying; He, Gui Xiang; Li, Hong Ye
- Abstract
Voxel-based morphometry (VBM) studies have provided cumulative evidence of gray matter (GM) atrophy in patients with progressive supranuclear palsy (PSP) relative to healthy controls (HC). However, not all findings have been entirely concordant. Herein, we performed a quantitative meta-analysis study in order to consistently quantify GM anomalies in PSP. We conducted a systematic search for VBM studies of PSP patients and HC using PubMed and Embase databases from January 2000 to May 2012. Meta-analysis of these VBM studies was performed using a newly improved voxel-based meta-analytic technique, effect-size signed differential mapping. A total of 9 cross-sectional VBM studies that involved 143 PSP patients and 216 HC subjects met the inclusion criteria. Considerable regional GM volume decrease was detected in the thalamus, basal ganglia, midbrain, insular cortex, and frontal cortex. These findings remained largely unchanged following jackknife sensitivity analyses. The present meta-analysis provided evidence of PSP-specific GM atrophy. This finding might help contribute to our understanding of the neurobiological basis underlying PSP.
- Publication
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013, Vol 34, Issue 7, p1049
- ISSN
1590-3478
- Publication type
Journal Article
- DOI
10.1007/s10072-013-1406-9