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- Title
Development of sarcoidosis in etanercept-treated rheumatoid arthritis patients.
- Authors
Verschueren, Kilian; Van Essche, Els; Verschueren, Patrick; Taelman, Veerle; Westhovens, Rene
- Abstract
We report two rheumatoid arthritis patients developing sarcoidosis possibly induced by etanercept. Both women, aged 46 and 53, had erosive, rheumatoid-factor-positive rheumatoid arthritis (RA) for 7 and 6 years, respectively. The eldest had received infliximab for over a year with good response, which was stopped because of a perfusion reaction. She developed a cough and dyspnea after 6 months of etanercept treatment. The other developed erythema nodosum and a plaque lesion on the right arm after 1 year of etanercept. Imaging showed, in both cases, mediastinal adenopathies. Biopsies were compatible with sarcoidosis. Etanercept withdrawal led to a complete remission. Recently, there have been reports of noninfectious granulomatous syndromes in patients receiving etanercept for a variety of diseases. In our cases, the temporal association with etanercept therapy and the complete remission after suspension of etanercept suggest a triggering role of this agent. Possible mechanisms of action and supporting evidence are discussed.
- Publication
Clinical rheumatology, 2007, Vol 26, Issue 11, p1969
- ISSN
0770-3198
- Publication type
Journal Article
- DOI
10.1007/s10067-007-0594-1