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- Title
EPITRANS: a database that integrates epigenome and transcriptome data.
- Authors
Cho, Soo Young; Chai, Jin Choul; Park, Soo Jun; Seo, Hyemyung; Sohn, Chae-Bong; Lee, Young Seek
- Abstract
Epigenetic modifications affect gene expression and thereby govern a wide range of biological processes such as differentiation, development and tumorigenesis. Recent initiatives to define genome-wide DNA methylation and histone modification profiles by microarray and sequencing methods have led to the construction of databases. These databases are repositories for international epigenetic consortiums or provide mining results from PubMed, but do not integrate the epigenetic information with gene expression changes. In order to overcome this limitation, we constructed EPITRANS, a novel database that visualizes the relationships between gene expression and epigenetic modifications. EPITRANS uses combined analysis of epigenetic modification and gene expression to search for cell function-related epigenetic and transcriptomic alterations (Freely available on the web at http://epitrans.org ).
- Publication
Molecules and cells, 2013, Vol 36, Issue 5, p472
- ISSN
0219-1032
- Publication type
Journal Article
- DOI
10.1007/s10059-013-0249-9