We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of retrotransposons in pluripotent stem cells.
- Authors
Tanaka, Yoshiaki; Chung, Leeyup; Park, In-Hyun
- Abstract
Retrotransposons, which constitute approximately 40% of the human genome, have the capacity to 'jump' across the genome. Their mobility contributes to oncogenesis, evolution, and genomic plasticity of the host genome. Induced pluripotent stem cells as well as embryonic stem cells are more susceptible than differentiated cells to genomic aberrations including insertion, deletion and duplication. Recent studies have revealed specific behaviors of retrotransposons in pluripotent cells. Here, we review recent progress in understanding retrotransposons and provide a perspective on the relationship between retrotransposons and genomic variation in pluripotent stem cells.
- Publication
Molecules and cells, 2012, Vol 34, Issue 6, p509
- ISSN
0219-1032
- Publication type
Journal Article
- DOI
10.1007/s10059-012-0242-8