We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols.
- Authors
Chaieb, L; Antal, A; Ambrus, G G; Paulus, W
- Abstract
Val66Met (rs6265) is a gene variation, a single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene that codes for the protein BDNF. The substitution of Met for Val occurs at position 66 in the pro-region of the BDNF gene and is responsible for altered activity-dependent release and recruitment of BDNF in neurons. This is believed to manifest itself in an altered ability in neuroplasticity induction and an increased predisposition toward a number of neurological disorders. Many studies using neuroplasticity-inducing protocols have investigated the impact of the BDNF polymorphism on cortical modulation and plasticity; however, the results are partly contradictory and dependent on the paradigm used in a given study. The aim of this review is to summarize recent knowledge on the relationship of this BDNF SNP and neuroplasticity.
- Publication
Neurogenetics, 2014, Vol 15, Issue 1, p1
- ISSN
1364-6753
- Publication type
Journal Article
- DOI
10.1007/s10048-014-0393-1