We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Myotonic dystrophy type 2 in Japan: ancestral origin distinct from Caucasian families.
- Authors
Saito, Tsukasa; Amakusa, Yoshinobu; Kimura, Takashi; Yahara, Osamu; Aizawa, Hitoshi; Ikeda, Yoshio; Day, John W; Ranum, Laura P W; Ohno, Kinji; Matsuura, Tohru
- Abstract
Myotonic dystrophy type 2 (DM2) is caused by expansion of a tetranucleotide CCTG repeat in intron 1 of the ZNF9 gene on chromosome 3q21. All studied DM2 mutations have been reported in Caucasians and share an identical haplotype, suggesting a common founder. We identified a Japanese patient with DM2 and showed that the affected haplotype is distinct from the previously identified DM2 haplotype shared among Caucasians. These data strongly suggest that DM2 expansion mutations originate from separate founders in Europe and Japan and are more widely distributed than previously recognized.
- Publication
Neurogenetics, 2008, Vol 9, Issue 1, p61
- ISSN
1364-6753
- Publication type
Journal Article
- DOI
10.1007/s10048-007-0110-4