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- Title
Contrast-enhanced ultrasound detects perfusion defects in an ex vivo porcine liver model: a useful tool for the study of hepatic reperfusion.
- Authors
Alzaraa, Ahmed; Al-Leswas, Dhya; Chung, Wen Yuan; Gravante, Gianpiero; Bruno, Morgan; West, Kevin; Dennison, Ashley; Lloyd, David
- Abstract
Following transplantation, areas of hypoperfusion can be associated with metabolic changes and poor organ recovery. Our study evaluated contrast-enhanced ultrasound (CEUS) agents for the detection of such areas. Livers were collected from ten pigs, connected to extracorporeal circuits and perfused using autologous blood. After 1 and 4 h livers were scanned with an ultrasound machine following the administration of CEUS agents. Biopsies from perfused and non-perfused areas were collected. The entire parenchyma enhanced strongly on non-contrast ultrasound at 1 h with no perfusion defects. Four hours later multiple perfusion defects manifested not evident with non-contrast ultrasound. Histology confirmed non-perfused areas corresponded to ischemic zones. In our model the addition of CEUS revealed perfusion defects after 4 h. This might facilitate detection and characterization of perfusion defects in transplanted livers.
- Publication
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2013, Vol 16, Issue 4, p475
- ISSN
1619-0904
- Publication type
Journal Article
- DOI
10.1007/s10047-013-0717-1