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- Title
Cloning and sequencing of a novel human gene which encodes a putative hydroxylase.
- Authors
Iriyama, C; Matsuda, S; Katsumata, R; Hamaguchi, M
- Abstract
Using a conventional two-hybrid technique with MAWD as bait protein, a novel full-length cDNA was isolated and sequenced from a human liver cDNA library. This cDNA consists of 2,575 base pairs and has a predicted open reading frame encoding 255 amino acids. Overall, it is similar to the catalytic enzyme PHZF, catalyzing the hydroxylation of phenazine-1-carboxylic acid to 2-hydroxyphenazine-1-carboxylic acid. Polymerase chain reaction-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 10q21.1 near the marker D10S210.
- Publication
Journal of human genetics, 2001, Vol 46, Issue 5, p289
- ISSN
1434-5161
- Publication type
Journal Article
- DOI
10.1007/s100380170081