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- Title
Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3.
- Authors
Matsuda, S; Iriyama, C; Yokozaki, S; Ichigotani, Y; Shirafuji, N; Yamaki, K; Hayakawa, T; Hamaguchi, M
- Abstract
By using a conventional two-hybrid technique with an Src homology 3 (SH3) domain of Nesh as the bait protein, a novel full-length cDNA was isolated and sequenced from a human placenta cDNA library. This cDNA consists of 3023 bp and has a predicted open reading frame that encodes 486 amino acids. It possesses an SH3 binding motif, a nuclear targeting sequence, and no catalytic domain. Overall, it has no similarity to known molecules involved in a signaling cascade. Polymerase Chair reaction-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels localized the gene on human chromosome 3q12 near the marker D3S1271.
- Publication
Journal of human genetics, 2001, Vol 46, Issue 8, p483
- ISSN
1434-5161
- Publication type
Journal Article
- DOI
10.1007/s100380170049