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- Title
Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family.
- Authors
Ichigotani, Y; Matsuda, S; Machida, K; Oshima, K; Iwamoto, T; Yamaki, K; Hayakawa, T; Hamaguchi, M
- Abstract
A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1,735 base pairs and has a predicted open reading frame (ORF) encoding 354 amino acids. It possesses a putative signal sequence, a long extracellular domain, a transmembrane region, a short intracellular domain, and no catalytic domain, which is highly homologous to signal-regulatory protein (SIRP)-beta suggesting that it seems to be a new member of the SIRP family. Polymerase chain reaction (PCR)-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 20p13 near the marker D20S906.
- Publication
Journal of human genetics, 2000, Vol 45, Issue 6, p378
- ISSN
1434-5161
- Publication type
Journal Article
- DOI
10.1007/s100380070013