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- Title
No association between atopic asthma and a coding variant of Fc epsilon R1 beta in a Japanese population.
- Authors
Ishizawa, M; Shibasaki, M; Yokouchi, Y; Noguchi, E; Arinami, T; Yamakawa-Kobayashi, K; Matsui, A; Hamaguchi, H
- Abstract
Susceptibility to atopic diseases is known to involve genetic factors. The Gly237 allele of a polymorphism (Glu237Gly) of the Fc epsilon R1 beta gene is reportedly associated with atopic asthma in Japanese. To confirm this association, we conducted transmission disequilibrium tests in 76 families identified through atopic asthmatics. A case-control study was also carried out in atopic asthmatic subjects and non-atopic controls. The Gly237 allele was not preferentially transmitted to atopic asthma-affected offspring. Neither the Gly237 allele nor the Gly237/Gly237 + Glu237/Gly237 genotypes were significantly more prevalent in the atopic asthmatics than in the controls. This study failed to confirm a substantial role of the Gly237Glu polymorphism of the Fc epsilon R1 beta gene in the genetic predisposition for atopic asthma in this Japanese population.
- Publication
Journal of human genetics, 1999, Vol 44, Issue 5, p308
- ISSN
1434-5161
- Publication type
Journal Article
- DOI
10.1007/s100380050166