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- Title
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
- Authors
Miyake, Kazuaki; Horikawa, Yukio; Hara, Kazuo; Yasuda, Kazuki; Osawa, Haruhiko; Furuta, Hiroto; Hirota, Yushi; Yamagata, Kazuya; Hinokio, Yoshinori; Oka, Yoshitomo; Iwasaki, Naoko; Iwamoto, Yasuhiko; Yamada, Yuichiro; Seino, Yutaka; Maegawa, Hiroshi; Kashiwagi, Atsunori; Yamamoto, Ken; Tokunaga, Katsushi; Takeda, Jun; Makino, Hideichi; Nanjo, Kishio; Kadowaki, Takashi; Kasuga, Masato
- Abstract
Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747-751, 2007) and Hayashi et al. (Diabetologia 50:980-984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR=1.48, P=2.7 x 10(-4); OR=1.39, P=4.6 x 10(-4); OR=1.70, P=9.8 x 10(-5), respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.
- Publication
Journal of human genetics, 2008, Vol 53, Issue 2, p174
- ISSN
1434-5161
- Publication type
Journal Article
- DOI
10.1007/s10038-007-0231-5