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- Title
Acute lymphoblastic leukemia with hypereosinophilia: report of a case with 5q deletion and review of the literature.
- Authors
Wynn, Tung T; Heerema, Nyla A; Hammond, Sue; Ranalli, Mark; Kahwash, Samir B
- Abstract
Peripheral blood eosinophilia as a presentation of acute lymphoblastic leukemia (ALL) has only rarely been reported. The eosinophilia is thought to be a nonneoplastic reaction to the neoplastic lymphoblasts. We present the case of a 5-year-old girl who developed peripheral hypereosinophilia with no circulating blasts prior to her diagnosis of B-cell lineage ALL. Cytogenetic study showed a hyperdiploid blast population with 5q deletion. Persistent peripheral hypereosinophilia should always be fully investigated, the possibility of a malignancy including ALL needs to be excluded, even in the absence of peripheral cytopenias and circulating blasts.
- Publication
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 2003, Vol 6, Issue 6, p558
- ISSN
1093-5266
- Publication type
Journal Article
- DOI
10.1007/s10024-003-2019-8