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- Title
Extraskeletal myxoid chondrosarcoma: a study using a quick-freezing and deep-etching method.
- Authors
Hemmi, Akihiro; Osaka, Shunzo; Sunagawa, Keishin; Kikuchi, Kentaro; Ohno, Nobuhiko; Terada, Nobuo; Fujii, Yasuhisa; Ohno, Shinichi; Nemoto, Norimichi
- Abstract
A case of extraskeletal myxoid chondrosarcoma (ESMC), which developed in the right thigh of a middle-aged Japanese woman, was studied using immunohistochemistry, conventional electron microscopy, and the quick-freezing and deep-etching (QF-DE) method. In addition to typical light microscopic findings of ESMC, conventional electron microscopy indicated that the tumor cells had features of chondrocytes. Immunohistochemically, the tumor cells showed a positive immunoreaction for S100 protein. A diagnosis of ESMC was made. An interesting observation was the ultrastructural features of collagen fibrils in the myxoid matrix highlighted by the QF-DE method. These collagen fibrils consisted of relatively thin collagen (20-35 nm) with pleated surface structures. The surface striation at 65 nm was obscure. We consider that such a finding of collagen fibrils identified by the QF-DE method is one of the characteristics of the myxoid matrix of ESMC, and this is useful for the differential diagnosis of myxoid soft tissue tumors.
- Publication
Medical molecular morphology, 2009, Vol 42, Issue 3, p180
- ISSN
1860-1499
- Publication type
Journal Article
- DOI
10.1007/s00795-009-0438-y