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- Title
Low-magnitude whole body vibration does not affect bone mass but does affect weight in ovariectomized rats.
- Authors
Jagt, Olav; Linden, Jacqueline; Waarsing, Jan; Verhaar, Jan; Weinans, Harrie
- Abstract
Mechanical loading has stimulating effects on bone architecture, which can potentially be used as a therapy for osteoporosis. We investigated the skeletal changes in the tibia of ovariectomized rats during treatment with whole body vibration (WBV). Different low-magnitude WBV treatment protocols were tested in a pilot experiment using ovariectomized rats with loading schemes of 2 × 8 min/day, 5 days/week ( n = 2 rats per protocol). Bone volume and architecture were evaluated during a 10 week follow-up using in-vivo microcomputed tomography scanning. The loading protocol in which a 45 Hz sine wave was applied at 2 Hz with an acceleration of 0.5 g showed an anabolic effect on bone and was therefore further analyzed in two groups of animals ( n = 6 each group) with WBV starting directly after or 3 weeks after ovariectomy and compared to a control (non-WBV) group at 0, 3, 6 and 10 weeks' follow-up. In the follow-up experiment the WBV stimulus did not significantly affect trabecular volume fraction or cortical bone volume in any of the treatment groups during the 10 week follow-up. WBV did reduce weight gain that was induced as a consequence of ovariectomy. We could not demonstrate any significant effects of WBV on bone loss as a consequence of ovariectomy in rats; however, the weight gain that normally results after ovariectomy was partly prevented. Treatment with WBV was not able to prevent bone loss during induced osteoporosis.
- Publication
Journal of Bone & Mineral Metabolism, 2012, Vol 30, Issue 1, p40
- ISSN
0914-8779
- Publication type
Academic Journal
- DOI
10.1007/s00774-011-0293-5