Title

Synthesis and in vitro evaluation of thiododecaborated α, α- cycloalkylamino acids for the treatment of malignant brain tumors by boron neutron capture therapy.

Authors

Hattori, Yoshihide; Kusaka, Shintaro; Mukumoto, Mari; Ishimura, Miki; Ohta, Yoichiro; Takenaka, Hiroshi; Uehara, Kouki; Asano, Tomoyuki; Suzuki, Minoru; Masunaga, Shin-ichiro; Ono, Koji; Tanimori, Shinji; Kirihata, Mitsunori

Abstract

Boron-neutron capture therapy (BNCT) is an attractive technique for cancer treatment. As such, α, α-cycloalkyl amino acids containing thiododecaborate ([BH]-S-) units were designed and synthesized as novel boron delivery agents for BNCT. In the present study, new thiododecaborate α, α-cycloalkyl amino acids were synthesized, and biological evaluation of the boron compounds as boron carrier for BNCT was carried out.

Subjects

AMINO acid synthesis; BRAIN tumor treatment; BORON-neutron capture therapy; BORON compounds; IMMUNOCYTOCHEMISTRY; IN vitro studies

Publication

Amino Acids, 2014, Vol 46, Issue 12, p2715

ISSN

0939-4451

Publication type

Academic Journal

DOI

10.1007/s00726-014-1829-5