We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Induction of type I interferon by RNA viruses: cellular receptors and their substrates.
- Authors
Baum, Alina; García-Sastre, Adolfo
- Abstract
Virus recognition and induction of interferon (IFN) are critical components of the innate immune system. The Toll-like receptor (TLR) and RIG-I-like receptor families have been characterized as key players in RNA virus detection. Signaling cascades initiated by these receptors are crucial for establishment of an IFN signaling mediated antiviral state in infected and neighboring cells and containment of virus replication as well as initiation of the adaptive immune response. In this review, we focus on the diverse and overlapping functions of these receptors, their physiological importance, and respective viral inducers. We highlight the roles of TRL3, TLR7/8, retinoic acid inducible gene I, melanoma differentiation-associated gene 5, and the RNA molecules responsible for activating these viral sensors.
- Publication
Amino acids, 2010, Vol 38, Issue 5, p1283
- ISSN
1438-2199
- Publication type
Journal Article
- DOI
10.1007/s00726-009-0374-0