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- Title
Lack of alternative coreceptor use by pediatric HIV-1 R5 isolates for infection of primary cord or adult peripheral blood mononuclear cells.
- Authors
Sullivan, W M; Dorr, P; Perros, M; Hudson, R; Leif, J; Luzuriaga, K; Clapham, P R
- Abstract
HIV-1 infection of neonates results in an extended acute period of virus replication, frequent neurological problems and reduced survival compared to adults. In adults, R5 viruses mainly infect CCR5(+) CD4(+) memory T-cells. In neonates, CCR5(+) memory T-cells form a substantially smaller fraction of total lymphocytes. We therefore tested whether alternative coreceptors confer infection of lymphocytes by pediatric isolates. Pediatric HIV-1 R5 isolates failed to replicate in Delta32/Delta32 CCR5 PBMCs or in cord PBMCs treated with a CCR5 inhibitor. These results do not indicate a role for alternative coreceptors and provide support for CCR5 inhibitors in the therapy of HIV-1(+) neonates.
- Publication
Archives of virology, 2008, Vol 153, Issue 2, p363
- ISSN
0304-8608
- Publication type
Journal Article
- DOI
10.1007/s00705-007-1099-6