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- Title
Differentiating attention-deficit/hyperactivity disorder inattentive and combined types: a <sup>1</sup>H-magnetic resonance spectroscopy study of fronto-striato-thalamic regions.
- Authors
Ferreira, Pedro E. M. S.; Palmini, André; Bau, Claiton D. H.; Grevet, Eugenio Horacio; Hoefel, João Rubião; Rohde, Luis Augusto; Anés, Maurício; Ferreira, Eloisa Elena; Belmonte-de-Abreu, Paulo
- Abstract
Despite the implication of fronto-striatal circuits in attention-deficit/hyperactivity disorder (ADHD), there is a lack of information on the role of these regions, especially the thalamus, in the heterogeneity of ADHD. We assessed the 1H-magnetic resonance spectroscopy profile in ventromedial prefrontal cortex (VMPFC)-thalamic-striatal regions bilaterally in three groups of subjects (age range 18–24 years old): ADHD inattentive type (ADHD-I; n = 9), ADHD combined type (ADHD-C; n = 10) and non-ADHD controls ( n = 12). The peaks of N-acetylaspartate, Choline (Cho), myo-inositol (mI), creatine (Cr) and glutamate-glutamine-GABA (Glx) to Cr were calculated. Subjects with ADHD-C showed lower mI/Cr ratio in the right VMPFC than controls, higher Cho/Cr ratio in the left thalamus-pulvinar than the ADHD-I group and higher Glx/Cr ratio in left putamen than individuals with ADHD-I and controls. This metabolic profile suggests a disruption of fronto-striato-thalamic structures in the ADHD-C as a result of lower neuronal energetic metabolism.
- Publication
Journal of Neural Transmission, 2009, Vol 116, Issue 5, p623
- ISSN
0300-9564
- Publication type
Academic Journal
- DOI
10.1007/s00702-009-0191-3