We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of CYP2D6 100 C > T and 2850 C > T polymorphisms with generalized tonic clonic seizures among Indians.
- Authors
Soundararajan, C C; Adhin, A; Tripathi, M; Prasad, H K; Jain, S; Vivekanandhan, S
- Abstract
Multiple avenues of research have provided evidence for the role of genetic and environmental factors in epilepsy. Previous studies indicated an association of debrisoquine hydroxylase (CYP2D6) with susceptibility to epilepsy. In this study, association of CYP2D6 100C > T and 2850C > T polymorphisms with generalized tonic clonic seizures (GTCS) among Indians has been analysed using case-control approach. A significant association of 2850C > T (P = 0.015) has been observed. Comparison between phenytoin toxic and others among patients showed no association of these polymorphisms with phenytoin toxicity.
- Publication
Journal of neural transmission (Vienna, Austria : 1996), 2006, Vol 113, Issue 12, p1873
- ISSN
0300-9564
- Publication type
Journal Article
- DOI
10.1007/s00702-006-0494-6