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- Title
Imaging of serotonin transporters and its blockade by citalopram in patients with major depression using a novel SPECT ligand [123I]-ADAM.
- Authors
Herold, N; Uebelhack, K; Franke, L; Amthauer, H; Luedemann, L; Bruhn, H; Felix, R; Uebelhack, R; Plotkin, M
- Abstract
We studied the midbrain SERT availability in patients with major depression and assessed the relation of SERT occupancy by citalopram to the treatment response. 21 non-medicated patients with major depression and 13 healthy controls were examined by [(123)I]-ADAM SPECT. The midbrain SERT availability (SERT V(3)'') was calculated using individual MRI scans. In 13/21 patients SPECT was repeated 7 days after oral medication with citalopram (10 mg/day). We found no significant difference in the mean midbrain SERT availability between the studied patients with major depression and healthy controls (0.86 +/- 0.27 vs. 0.71 +/- 0.44, p = 0.069). The mean SERT occupancy accounted to 61%. The degree of SERT blockade by citalopram did not correlate with the reduction in HAMD total score. Treatment with low-dosed citalopram caused individually variable occupancy of the midbrain-SERT and a rapid clinical improvement in 54% of the investigated patients.
- Publication
Journal of neural transmission (Vienna, Austria : 1996), 2006, Vol 113, Issue 5, p659
- ISSN
0300-9564
- Publication type
Journal Article
- DOI
10.1007/s00702-005-0429-7