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- Title
High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study.
- Authors
Graf, M; Ecker, D; Horowski, R; Kramer, B; Riederer, P; Gerlach, M; Hager, C; Ludolph, A C; Becker, G; Osterhage, J; Jost, W H; Schrank, B; Stein, C; Kostopulos, P; Lubik, S; Wekwerth, K; Dengler, R; Troeger, M; Wuerz, A; Hoge, A; Schrader, C; Schimke, N; Krampfl, K; Petri, S; Zierz, S; Eger, K; Neudecker, S; Traufeller, K; Sievert, M; Neundörfer, B; Hecht, M; German vitamin E/ALS Study Group
- Abstract
Increasing evidence has suggested that oxidative stress may be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). The antioxidant vitamin E (alpha-tocopherol) has been shown to slow down the onset and progression of the paralysis in transgenic mice expressing a mutation in the superoxide dismutase gene found in certain forms of familial ALS. The current study, a double blind, placebo-controlled, randomised, stratified, parallel-group clinical trial, was designed to determine whether vitamin E (5000 mg per day) may be efficacious in slowing down disease progression when added to riluzole.
- Publication
Journal of neural transmission (Vienna, Austria : 1996), 2005, Vol 112, Issue 5, p649
- ISSN
0300-9564
- Publication type
Journal Article
- DOI
10.1007/s00702-004-0220-1