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- Title
Ischaemic preconditioning of the brain, mechanisms and applications.
- Authors
Steiger, H-J; Hänggi, D
- Abstract
The concept of ischaemic preconditioning was introduced in the late 1980s. The concept emerged that a brief subcritical ischaemic challenge could mobilize intrinsic protective mechanisms that increased tolerance against subsequent critical ischaemia. Tissues with a high sensitivity against ischaemia, i.e. myocardium and central nervous system, present the most promising targets for therapeutic application of ischaemic preconditioning. During the last years the mechanisms of neuronal preconditioning were systematically studied and a number of molecular regulation pathways were discovered to participate in preconditioning. The purpose of the present review is to survey the actual knowledge on cerebral preconditioning, and to define the practical impact for neurosurgery.
- Publication
Acta neurochirurgica, 2007, Vol 149, Issue 1, p1
- ISSN
0001-6268
- Publication type
Journal Article
- DOI
10.1007/s00701-006-1057-1