Title

Circulating mitochondrial DNA is decreased in children and adolescents with obesity and/or insulin resistance.

Authors

Morandi, Anita; Zusi, Chiara; Corradi, Massimiliano; Takemoto, Koji; Contreas, Giovanna; Olivieri, Francesca; Fornari, Elena; Maffeis, Claudio

Abstract

1 Variation of the circulating mtDNA according to gender and obesity status Discussion This study shows an inverse association between circulating mtDNA and obesity in children and adolescents. Assuming that c-mtDNA reflects mitochondrial function, boys could be more prone than girls to obesity due to mitochondrial dysfunction or to mitochondrial dysfunction due to obesity or both.

Subjects

ADOLESCENT obesity; CHILDHOOD obesity; MITOCHONDRIAL DNA; INSULIN resistance; NADH dehydrogenase

Publication

Acta Diabetologica, 2020, Vol 57, Issue 5, p623

ISSN

0940-5429

Publication type

Academic Journal

DOI

10.1007/s00592-019-01471-x