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- Title
Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells.
- Authors
Kappe, Camilla; Patrone, Cesare; Holst, Jens J; Zhang, Qimin; Sjöholm, Ake
- Abstract
Metformin is the most frequently prescribed drug for treatment of type 2 diabetes. It improves insulin resistance and glycemia by reducing hepatic gluconeogenesis. In addition, diabetic patients on metformin therapy have elevated levels of the insulinotropic hormone glucagon-like peptide-1 (GLP-1) and metformin has been shown to regulate the expression of the GLP-1R in the pancreas.
- Publication
Journal of gastroenterology, 2013, Vol 48, Issue 3, p322
- ISSN
1435-5922
- Publication type
Journal Article
- DOI
10.1007/s00535-012-0637-5